† When you’ve been using this drug for longer than a several months, don’t stop taking it with no speaking with your healthcare provider. You’ll have to taper off the drug slowly and gradually to stay away from withdrawal signs and symptoms including stress, sweating, nausea, diarrhea, and difficulty sleeping.
Although significant, existence-threatening, or fatal respiratory melancholy can occur Anytime in the course of the usage of DILAUDID INJECTION, the risk is greatest over the initiation of therapy or subsequent a dosage improve.
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If you're possessing operation, such as dental surgical treatment, inform the health practitioner or dentist that you are applying hydromorphone injection.
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emphasize to sufferers as well as their caregivers the value of examining the Medication Guidebook when it really is furnished by their pharmacist, and
The concomitant use of opioids with other prescription drugs that have an impact on the serotonergic neurotransmitter procedure has resulted in serotonin syndrome.
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The pharmacokinetics of hydromorphone are affected by hepatic impairment. On account of elevated exposure of hydromorphone, sufferers with average hepatic impairment ought to be began at just one-fourth to at least one-half the advised starting off dose with regards to the diploma of hepatic dysfunction and closely monitored in the course of dose titration.